Download e-book for kindle: Ankylosing spondylitis and Klebsiella by Alan Ebringer


By Alan Ebringer

ISBN-10: 1447142993

ISBN-13: 9781447142997

ISBN-10: 1447143000

ISBN-13: 9781447143000

Ankylosing spondylitis and Klebsiella is a finished and informative textual content at the explanation for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a situation which impacts 20 million humans around the globe and is probably going brought on or initiated via a bowel an infection from Klebsiella bacteria.

When a sufferer is contaminated through Klebsiella bacteria, his or her immune process will make antibodies opposed to all of the antigens or molecules present in the microbe. simply because a few of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues comparable to the joints and the cells having an analogous HLA molecules, that is how the disorder AS starts off. this is often the concept that of molecular similarity or “molecular mimicry” which formerly has been came upon to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.

The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological subject matters were released, from Prof Ebringer’s workforce, on the department of lifestyles Sciences, King’s university in London, united kingdom.

The correct info from those papers is extracted and provided during this e-book layout making it obtainable to health and wellbeing execs, study associations, pharmaceutical businesses and universities and most of the people.

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Additional info for Ankylosing spondylitis and Klebsiella

Sample text

At the same the American group published their tissue typing studies on ankylosing spondylitis patients carried out in Professor Terasaki’s Laboratory in Los Angeles (Schlosstein et al. 1973). 3 Acute Anterior Uveitis and HLA-B27 Some 30 % of ankylosing spondylitis patients develop an episode of uveitis during their lifetime. The Westminster group investigated a group of ophthalmological patients with acute anterior uveitis. HLA-B27 was identified in 26 out of 50 patients suffering from acute anterior uveitis, but only 2 out of 50 of the control subjects possessed the HLA-B27 antigen (Brewerton et al.

4 Haemagglutination Method Sheep erythrocytes in Alsever’s solution (Oxoid Ltd) were coated with lipopolysaccharide (LPS) extract prepared from Klebsiella pneumoniae microorganisms by the phenol water-extraction method (Westphal et al. 1952). Erythrocytes at a concentration of 4 % in PBS were incubated at 37 °C for 1 h with 40 mg of Klebsiella LPS, washed three times in PBS and resuspended to a final concentration of 1 %. 5 % normal rabbit serum in haemagglutination plates. Equal amounts of cell suspensions were added to each well, incubated at 37 °C for 1 h, then overnight at 4 °C and the highest dilution showing agglutination read as the end point.

N Engl J Med. 1973;288:704–6. 1 Introduction: The Problem of HLA-B27 in Ankylosing Spondylitis Many diseases are associated with HLA antigens. For instance, rheumatoid arthritis is found more frequently in individuals possessing HLA-DR1 and HLA-DR4 antigens. The strongest and best documented association shows that individuals who carry HLA-B27 have a high risk of developing ankylosing spondylitis. The high frequency of HLA-B27 in these patients could be explained either by a susceptibility gene closely linked to HLA-B27 or to direct involvement of the HLAB27 molecule through ‘molecular mimicry’.

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Ankylosing spondylitis and Klebsiella by Alan Ebringer

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