New PDF release: Applied Dermatotoxicology. Clinical Aspects

Dermatology

By Howard Maibach, Golara Honari

ISBN-10: 012420130X

ISBN-13: 9780124201309

Applied Dermatotoxicology: medical Aspects offers concise, systematic, and state of the art details at the toxicological results of drugs on dermis, and up to date advances in dermal toxicity checking out.

This booklet in particular addresses the scientific displays borne out of publicity to various chemical substances. It starts with an outline of epidermis biology to supply toxicologists with a simple figuring out of its anatomy and body structure. subsequent it provides numerous dermatotoxicological results, to boot on the poisonous brokers that reason them, with colour pictures to demonstrate those results.

Applied Dermatotoxicology: medical Aspects is an important reference for toxicologists in undefined, and for these doctors who come across circumstances of dermal publicity to poisonous brokers.

  • A concise, but inclusive assessment of results of chemical exposure
  • Includes heritage on uncomplicated dermis biology
  • Provides important scientific reference for toxicologists in non-clinical settings

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Extra info for Applied Dermatotoxicology. Clinical Aspects

Example text

However, they can vary from urticarial, eczematous, lichenoid, or pigmentary changes. Clinical distinction between phototoxic and photoallergic reactions is difficult; also both conditions can exist concomitantly. Photoallergens and photoactive agents may have irritancy potentials as well. 1. 1 Key Features of Photosensitivity Reactions Phototoxic Reactions Photoallergic Reactions Incidence High Low Sensitization required No Yes Clinical presentation Sunburn-like reaction, erythema, edema with or without blistering, burning and painful, sharply demarcated Eczematous, itchy Onset of symptoms Minutes to hours after photoexposure 24À48 h after photoexposure Pathophysiology Direct cell damage, DNA damage, ROS, inflammation Type IV hypersensitivity photoproduct Histology Epidermal necrosis, dermal edema Spongiotic dermatitis, dermal lymphohistiocytic infiltrate Cross-reactivity No Often Diagnosis Clinical and phototests Clinical and photopatch tests Photoirritation (Phototoxicity): Clinical Aspects 45 Distribution of skin lesions in phototoxicity depends on whether the photoactive chemical is topically applied (photocontact dermatitis) or a systemic photosensitizer is the cause of reaction.

17. Joint Research Centre of The European Commission’s in-house science service. pdf. 14. 18. Basketter DA, York M, McFadden JP, Robinson MK. Determination of skin irritation potential in the human 4-h patch test. Contact Dermatitis. 2004;51(1):1À4. 19. Patil SM, Patrick E, Maibach HI. Animal, human, and in vitro test methods for predicting skin irritation. In: Marzulli FN, Maibach HI, eds. Dermatotoxicology Methods. Washington, DC, USA: CRC Press; 1998:89À114. 20. Jirova D, Basketter D, Liebsch M, et al.

1979;1(1):35À41. 24. Kooyman DJ, Snyder FM. Tests for the mildness of soaps. Arch Dermatol Syph. 1942;46:846À855. 25. Gabard B, Chatelain E, Bieli E, Haas S. Surfactant irritation: in vitro corneosurfametry and in vivo bioengineering. Skin Res Technol. 2001;7(1):49À55. 26. Laudanska H, Reduta T, Szmitkowska D. Evaluation of skin barrier function in allergic contact dermatitis and atopic dermatitis using method of the continuous TEWL measurement. Rocz Akad Med Bialymst. 2003;48:123À127. 27. Bircher A, de Boer EM, Agner T, Wahlberg JE, Serup J.

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Applied Dermatotoxicology. Clinical Aspects by Howard Maibach, Golara Honari


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